Karlos Williams guarantees LeSean McCoy will be 100 percent

DE Mario Williams played only a few plays Thursday because of an illness.

With Williams and defensive tackle Kyle Williams, the Bills had to turn to Corbin Bryant and Alex Carrington up front.

Karlos Williams rushed seven times for 24 yards in Buffalo’s Week 10 win over the Jets, adding a 26-yard touchdown reception. “And Josh was really – he knew the game plan going in….” It marked the first time Manuel, whom the Bills selected in the first round of the 2013 draft, was a healthy inactive. However, he gashed one of the best run defenses in the league Thursday, looking as spry as ever in finishing with 112 yards on 19 carries. Defensively, NY is allowing 20.3 points and 323.3 yards per game. He might still be playing behind LeSean McCoy, but the Bills have something special to cultivate in Williams. The Jets are just way more of a balanced football team and should be able to get the job done on short rest. It’s his first game against the Jets since the team made the decision to part ways with him, and knowing Ryan he’s probably out for revenge.

“What happened was, we had a short week”, Ryan said. Fitzpatrick is a limited passer when he’s not injured, so there’s no reason to think that he’ll have any sort of success against Ronald Darby and Stephon Gilmore. After a tough start to the season, Hughes managed to get two sacks against the Dolphins and it looked like he was back to his old ways. “I hope we can”, he said.

After a record-setting day against Miami last weekend, Buffalo’s offense was bad in the beginning, good in the middle, and bad at the end, except for a crucial final drive in which it grounded out two first downs and left the Jets just 24 seconds on the clock, enough time for ex-Bill Ryan Fitzpatrick to throw the clinching interception for his team. The Bills will want to win this one for their head coach.