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The U.S. on Wednesday launched its first airstrikes by Turkey-based F-16 fighter jets against Islamic State targets in Syria, marking a limited escalation of a yearlong air campaign that critics have called excessively cautious.

The response from Washington came with Mark Toner from the US State Department emphasizing “We’ve been pretty clear from the podium and elsewhere saying there’s no zone, no safe haven-we’re not talking about that here. What our minister pointed out is that...

Turkey said on Tuesday it had agreed with the United States on terms for setting up a “safe zone” inside northern Syria as part of their campaign against Islamic State militants, but the US State Department denied there was any such agreement.

A US drone had last week executed a single lethal airstrike against an ISIS target in Syria but this was the first time manned US fighter jets had carried out raids after taking off from Turkey’s strategically-located Incirlik base.

Missouri The United States presented its first manned air strikes against Islamic State manages from the Incirlik Air Base in Turkey on Wednesday, the You can introduce.S. navy said.

Thought it opposes Islamic State, the Nusra Front last month attacked rebels trained as part of a U.S.-led program to bolster insurgents viewed as moderate enough to fight the ultra-hardline group.

On Wednesday, the Pentagon said U.S. jets now based at Incirlik Air Base in southern Turkey had hit their first targets in Syria, which American officials cheered as a significant step forward.

Under the strategy, moderate Syrian rebels, trained by the US Army, will fight the militant group on the ground and help coordinate air strikes by the US coalition, launched from Turkish air bases.

Wednesday saw U.S. warplanes deploy for airstrikes on Islamic State (IS) targets in Syria after taking off from a Turkish base, for the first time.

Three people have been killed and seven wounded in clashes between Turkish security forces and suspected PKK militants in the Kurdish town of Silopi.

Turkey and the U.

Turkey has faced increasing insecurity along its 900-km (560-mile) border with Syria.