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The agreement is expected to face its biggest challenge in the U.S. Congress, for which a 60-day period began Monday to review it before voting on whether or not to endorse it.

With the adoption of the resolution here, the 15-nation body endorsed the landmark nuclear deal entered into between Iran and P5+1 nations of China, France, Russia, the United Kingdom and the United States, plus Germany last week. The 14-page U.N. resolution is legally binding...